Diabetic Nephropathy: Treatment & Medication

Angiotensin receptor blockers

Specific and selective angiotensin II receptor antagonists.3 Compared with ACE inhibitors, ARBs are associated with a lower incidence of drug-induced cough, rash, and/or taste disturbances.The effect of aliskiren, a direct renin inhibitor, on proteinuria in patients with type 2 diabetes mellitus (n = 26) was assessed and compared with that of placebo, irbesartan (an ARB), and the combination of aliskiren and irbesartan.8

The study was a double-blind, randomized, crossover trial. Patients were assigned to four 2-month treatments in random order. Monotherapy with either aliskiren or irbesartan significantly improved albuminuria when compared with placebo (P <0.001). p =" 0.028)." href="http://emedicine.medscape.com/article/238946-treatment?src=emed_whatnew_nl_0#Albumin">http://emedicine.medscape.com/article/238946-treatment?src=emed_whatnew_nl_0#Albumin