Asymptomatic hyperuricemia that occurs independently of gout might not be benign. Substantial, growing epidemiologic and experimental biologic evidence (reviewed in detail elsewhere) indicates that asymptomatic hyperuricemia is capable of directly promoting hypertension and vascular disease. For example, soluble urate is an antioxidant, but urate also can be converted to pro-oxidants that can affect the disposition of the vasodilator, nitric oxide, and thereby potentially regulate vascular endothelial cell function.
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