Washington, DC - A long-term prospective study of bariatric surgery for weight loss in obese individuals showed the procedure has no effect on the rates of MI when compared with individuals who underwent conventional care.
While the rates of MI were equivalent in follow-up out to 20 years, investigators suggest there was a significant effect of surgery on fatal and nonfatal MI in subjects with elevated baseline glucose levels.
"Patients with elevated glucose levels are at higher risk, and it is reduced with surgery," lead investigator Dr Lars Sjöström (Gothenburg University, Sweden) told heartwire. "For patients with lower glucose levels, those below the median, glucose levels aren't reduced as much, so we're unable to reduce the outcome on myocardial infarction in the same way when compared with those who have higher levels."He cautioned, however, against making too much of the MI benefit with surgery in patients with elevated glucose levels, because the analysis was post hoc and needs to be confirmed in other studies.The results of the study, an analysis of the Swedish Obese Subjects (SOS) study, were presented here this week during the late-breaking clinical-trials session at Obesity 2009.
Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on Swedish obese subjects. N Engl J Med 2007; 357:741-752.
Fuente original: theheart.org
While the rates of MI were equivalent in follow-up out to 20 years, investigators suggest there was a significant effect of surgery on fatal and nonfatal MI in subjects with elevated baseline glucose levels.
"Patients with elevated glucose levels are at higher risk, and it is reduced with surgery," lead investigator Dr Lars Sjöström (Gothenburg University, Sweden) told heartwire. "For patients with lower glucose levels, those below the median, glucose levels aren't reduced as much, so we're unable to reduce the outcome on myocardial infarction in the same way when compared with those who have higher levels."He cautioned, however, against making too much of the MI benefit with surgery in patients with elevated glucose levels, because the analysis was post hoc and needs to be confirmed in other studies.The results of the study, an analysis of the Swedish Obese Subjects (SOS) study, were presented here this week during the late-breaking clinical-trials session at Obesity 2009.
Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on Swedish obese subjects. N Engl J Med 2007; 357:741-752.
Fuente original: theheart.org
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