domingo, 23 de febrero de 2014

Brain and Islet: Key Partners in Glucose Homeostasis

The idea that the brain plays an important role in glucose homeostasis is not exactly new, though it has been overlooked for quite some time. In the 19th century, Claude Bernard induced diabetes in rabbits by injuring the floor of the fourth cerebral ventricle.1 The discovery of insulin in 1921, however, drew attention away from the brain-centered view of diabetes. Since then, the islet-centered view has dominated. Recently, an international group of researchers has proposed to revive the brain-centered theory. In a review article published in the journal Nature, scientists from the US and Germany describe a brain-centered glucoregulatory system (BCGS) that helps maintain glucose homeostasis via insulin-dependent and insulin-independent mechanisms.2 - See more at:


No hay comentarios:

Publicar un comentario