new, four–drug cocktail has shown a novel ability to reverse established Type 1 diabetes in some mice, University of Florida Health researchers have found. Fifty percent of mice that were treated with the four drugs had their established diabetes go into remission, according to the findings. The drug cocktail also succeeded in reversing new–onset cases of Type 1 diabetes in 83 percent of the mice. But it’s the drugs’ effectiveness with established cases that is particularly encouraging because that has the most potential to translate into helping human patients, said Michael Haller, M.D., an associate professor of pediatrics in the UF College of Medicine and a pediatric endocrinologist with the UF Diabetes Institute. The findings were published recently in the journal Diabetes. The combination treatment also may be more translatable to human clinical trials because it uses a lower dose of the drug thymoglobulin, which researchers said makes it safer and causes fewer side effects. In addition to thymoglobulin, the other drugs tested were granulocyte–colony stimulating factor, a dipeptidyl peptidase IV inhibitor and a proton pump inhibitor. When used together, the four drugs have a synergy that makes them substantially more effective than they are individually, researchers found. The study did not determine why the four–drug cocktail was effective in some mice but not others.