Triple therapy for new-onset diabetes: A paradigm shift?

Chicago, IL - A novel approach of starting newly diagnosed type 2 diabetes patients on three therapeutic agents simultaneously showed greater and more durable reductions in HbA_1c, less hypoglycemia, and less weight gain compared with conventional, stepwise add-on treatment in a new study reported yesterday here at the American Diabetes Association (ADA) 2013 Scientific Sessions [1].

The results of this so-called "triple therapy," in this case metformin, pioglitazone, and the glucagonlike peptide-1 (GLP-1) agonist exenatide (Byetta, AstraZeneca/Bristol-Myers Squibb Alliance), were hailed as potentially revolutionary and possibly "paradigm shifting," although questions remain.

The comparator stepwise add-on regimen was with metformin, a sulfonylurea (glyburide), and basal insulin glargine.

 

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